Aligned with the latest CBME curriculum, the 6th edition of Textbook of Biochemistrycontinues its long-standing tradition of clarity, rigour, and clinical relevance. Thoroughly revised with focused updates and enriched with emerging topics such as AI in biochemistry, it offers a cohesive and integrated approach to learning. Its sustained emphasis on conceptual understanding, clinical correlation, and a student-centred design reinforces its status as a definitive core resource for competency-based medical education and assessment.
Aspirants of NEET PG, USMLE, PLAB and other global entrance examinations will also find the book well suited to their needs.
Salient Features
Rafi MD is the Dean and Medical Director of Surabhi Institute of Medical Sciences, Siddipet, Telangana.
A Mapping of the Contents of the Book to the CBME Curriculum Preface to the Sixth Edition Acknowledgements How to Use This Book and Its Special Features Preface to the First Edition
I Prelude — Molecular and Functional Organisation of Life 1. Learning Biochemistry 2. The Cell and Biological Membranes: Structure and Function
II Molecules of Life 3. Carbohydrates 4. Lipids 5. Amino Acids and Proteins 6. Nucleotides and Nucleic Acids 7. Enzymes 8. Clinical Enzymology 9. Fat-soluble Vitamins and Associated Diseases 10. Water-Soluble Vitamins and Associated Diseases
III Physiological Biochemistry 11. Biochemistry of Blood and Associated Diseases 12. Hemoglobin, the Chemistry of Respiration, and Associated Disorders 13. Heme Synthesis, Degradation, and Associated Diseases 14. Digestion, Absorption, and Associated Diseases
IV Metabolism 15. A Journey into Metabolism 16. Central Metabolism: Krebs Cycle and Biological Oxidation 17. Metabolism of Carbohydrates 18. Blood Glucose Homeostasis, Pancreatic Hormones, and Diabetes Mellitus 19. Metabolism of Lipids 20. Metabolism of Cholesterol, Lipoproteins, and Diseases Associated with Lipid Metabolism 21. Metabolism of Amino Acids—General Aspects 22. Metabolism of Individual Amino Acids and Diseases Associated with Them 23. Metabolism of Nucleotides and Associated Diseases 24. Integration of Metabolism 25. Metabolism of Xenobiotics: Detoxification and Biotransformation
V Nutrition 26. Minerals and Associated Diseases 27. Principles of Nutrition and Nutritional Disorders
VI Clinical Biochemistry 28. Water and Electrolytes and Associated Disorders 29. Acid–Base Balance and Associated Disorders 30. Organ Function Tests 31. Biochemistry of Cancer
VII Molecular Biology 32. DNA Metabolism 33. RNA Metabolism 34. Protein Biosynthesis 35. Regulation of Gene Expression
VIII Biotechnology and Immunology 36. Recombinant DNA Technology 37. Molecular Diagnostics 38. Biochemical Techniques and Quality Control in Clinical Laboratories 39. Immunochemistry
IX Biochemical Perspective of Endocrinology 40. Hormone Action 41. Hypothalamic and Pituitary Hormones and Associated Diseases 42. Thyroid Hormones and Associated Disorders 43. Hormones of the Adrenal Gland and Associated Diseases 44. Hormones of the Gonads and Associated Diseases
X Contemporary Topics 45. Extracellular Matrix and Connective Tissue Diseases 46. Reactive Oxygen Species and Antioxidants 47. Biochemical Genetics, Prenatal and Newborn Screening 48. Environmental Pollutants, Toxins, and Biomedical Waste Management 49. Human Genome Project, Bioinformatics, and Gene Therapy 50. Artificial Intelligence in Clinical Biochemistry Laboratory Practices
Appendices A1 Attitude, Ethics, and Communication (AETCOM) A2 Reference Values and Interpretation of Biochemical Parameters: A Ready Clinical Reference
Index
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